STIs are spread through skin-to-skin contact and through vaginal, anal, and oral sex. Skin-to-skin contact does not mean walking up to someone and touching that person. It means coming into contact with an infected area. HPV (Human Papillomavirus) and Herpes are spread through skin-to-skin contact. It is not necessary to have sexual intercourse to contract these STIs. Other STIs like Chlamydia, Gonorrhea, Syphilis, HIV, and Hepatitis B are spread through bodily fluids like blood, urine, semen, and vaginal fluid, which are exchanged during vaginal, anal, and oral sex.